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Originally Posted by bangali_babu  yes, you are right about creatine's abusive effects but: in an ideal scenario, one shouldn't take any kind of supplements (vitamins or proteins). any kind of need for extra nutrients should be complimented by proper food (not processed food).
but we don't live in an ideal world and human life is too short to be lived idealistically. there are far more greater chances of one's death due to accidents then of old age. so we end up living in the fast lane, expecting fast results. i believe, human body has evolved upto some extent to be able to process "processed" food (health supplements and canned food etc.). anything taken in moderation won't cause permanent damage.
coming back to the discussion of creatine: it's often advised to cycle creatine usage. some people have a heavy "loading" phase and then quit for a couple of months. some people (like me), just take 5ml of creatine for 3 months on and off. everybody has different needs and everybody can't digest creatine too easily. people need to try out different doses and if it doesn't suit them then maybe this stuff is not meant for them. your body can tell you if the stuff is not good for you.
i am not refuting your advice but then if we want to live a disease free life then we need to get rid of all the junk food, trans fats and other such stuff.
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I doubt that you would understand this but let me try. In a study conducted by a group of doctors and scientists ( Not appointed by food supplement companies and had no conflict of interests ) namely 'Insulin resistance with creatine supplementation in laboratory animal' published in 'Rev Bras Med Esporte Vol-13, Jan-Feb 2007' observed that Study group (Comprising of rats who received creatine supplementation for 4 weeks) developed insulin resistance and their glucose level were significantly higher in comparison to control group ( who didn't receive supplementation )
Now let me give you reasons, It causes Insulin hyper secretion which eventually lead to resistance.
Do you know how we get energy to act ? ATP's found in our body are our biological currency ( Adenosin Tri Phosphate) This Tri-Phosphate gives a phosphate atom and gives us energy to work ( Turning in to Di-phosphate in process ) now unfortunately our bodies only have enough ATP's to give us energy to work for few seconds, then glycogen in our muscle with start breaking up making glucose which would undergo anaerobic glycolysis, Converting ADP's into ATP's (Which gives us again energy) and the cycle repeats. Now here in this anaerobic glycolysis end product is lactic acid which makes your muscles feel exhausted ( Nature's mechanism so one can't work out much without proper practice/training etc ). If this lactic acid wasn't in your muscles, you wouldn't feel tired in response to exercise. Now here comes your creatine mono hydrate in play, It has an extra phosphate, So it can reconvert ADP into ATP without undergoing anaerobic glycolysis ( No lactic acid, less tiredness ) and it causes water retention ( muscles appears full ) what a wonderful creation for supplementation companies ? They gets the money, you get to exercise more, your muscles appear full and everybody lives happily ever after ? Sadly no
It increases insulin secretion and changes muscles receptor's sensitivity to insulin causing insulin resistance and eventually impaired glucose tolerance/diabetes. Now how long it will take ? I guess ( GUESS) it would depend on number of factors, Your chances of developing insulin resistance at later age, amount of creatine, duration of use and how you take it, in my hypothesis if you take it without mixing it with glucose and you are susceptible to develop diabetes in old age, it might as well take less then a month.
My Advise, Stay away from this. Rest if your choice.
> Is Creatine harmful???
5th February 2013
you comparing rats to humans?
